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In terms of discharging water, kidney is the main organ in the body. When the kidney is sicken, water can not be discharged from the body, thus forming retention in the body, and it is called nephrotic edema. When the condition of patients with NS aggravates, an obvious and generalized edema will occur, and even worse, pleural effusion and ascites will also occur. And the patients' body weight will increase dozens of kilogrames(severe edema).