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Antidepressant prescribing has risen nearly 400% since 1988, according to data from the Centers for Disease Control and Prevention (CDC). More than 1 in 10 Americans over age 12 now take an antidepressant, the study finds, and yet two-thirds of those with severe symptoms of depression do not take antidepressants at all. The new research, led by CDC epidemiologist Laura Pratt, was based on responses from about 12,000 people who took part in a national annual health survey in 2005-08 and was released Wednesday as a National Center for Health Statistics Data Brief.